A Queensland State of Origin representative outside back, he has played his entire NRL career to date at the Storm, winning the 2009, 2012 and 2017 Grand Finals with them. Chambers also played rugby union for the Queensland Reds 2010-11 and for Munster. After a great start to the 2015 season, Chambers became the 800th Australian Kangaroo. He made his test debut in the centres against New Zealand Kiwis in the 2015 Anzac Test at Suncorp Stadium.